Epigenetic and Mitochondrial Cross-talk In HFpEF

Edwin Yoo

Histone post-translational analysis using mass spectrometry provides a unique vantage point to cellular regulation of gene expression. Using this unique approach, I have characterized the histone post-translational modification landscape in human HFpEF endomyocardial biopsies and have uncovered novel relationships between epigenetic marks and mitochondrial metabolism. My project elucidates the mechanisms by which metabolites influence histone PTMs, and vice-versa, and novel ways to target these signaling pathways are being tested in relevant animal models.