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RECENT PUBLICATIONS
INHIBITION OF PHOSPHODIESTERASE TYPE 9 REDUCES OBESITY AND CARDIOMETABOLIC SYNDROME IN MICE
Nov 2021
PDE1 INHIBITION MODULATES CAV1.2 CHANNEL TO STIMULATE CARDIOMYOCYTE CONTRACTION
Sep 2021 Circ Res
ACUTE HEMODYNAMIC EFFECTS AND TOLERABILITY OF PHOSPHODIESTERASE-1 INHIBITION WITH ITI-214 IN HUMAN SYSTOLIC HEART FAILURE
Aug 2021 Circ Heart Fail
CELLULAR AND MOLECULAR PATHOBIOLOGY OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
Jan 2021 Nature Reviews Cardiology
REDUCED RIGHT VENTRICULAR SARCOMERE CONTRACTILITY IN HFPEF WITH SEVERE OBESITY
Dec 2020 Circulation
MYOCARDIAL GENE EXPRESSION SIGNATURES IN HUMAN HEART FAILURE WITH PRESERVED EJECTION FRACTION
Oct 2020 Circulation
CHIP PHOSPHORYLATION BY PROTEIN KINASE G ENHANCES PROTEIN QUALITY CONTROL AND ATTENUATES CARDIAC ISCHEMIC INJURY
Oct 2020 Nat Comm
RECENT HFPEF WORK
October 2020
TARGETING PROTEIN KINASE G TO TREAT CARDIAC PROTEOTOXICITY
July 2020 Front Physiol
PKG1Α CYSTEINE-42 REDOX STATE CONTROLS MTORC1 ACTIVATION IN PATHOLOGICAL CARDIAC HYPERTROPHY
July 2020 Circ Res
ENDOMYOCARDIAL BIOPSY CHARACTERIZATION OF HEART FAILURE WITH PRESERVED EJECTION FRACTION AND PREVALENCE OF CARDIAC AMYLOIDOSIS
July 2020 JACC Heart Failure
OBESITY COULD SHIFT SEVERE COVID-19 DISEASE TO YOUNGER AGES
May 2020 Lancet
LEVERAGING SIGNALING PATHWAYS TO TREAT HEART FAILURE WITH REDUCED EJECTION FRACTION.
May 2019 Circ Res
IN VIVO SELECTIVE INHIBITION OF TRPC6 BY ANTAGONIST BI 749327 AMELIORATES FIBROSIS AND DYSFUNCTION IN CARDIAC AND RENAL DISEASE
April 2019 PNAS
PKG1-MODIFIED TSC2 REGULATES MTORC1 ACTIVITY TO COUNTER ADVERSE CARDIAC STRESS
January 2019 Nature
CHRONIC ATRIAL AND VENTRICULAR PACING IN THE MOUSE
February 2019 Circ Heart Fail
MARKED DISPARITY OF MICRORNA MODULATION BY CGMP-SELECTIVE PDE5 VERSUS PDE9 INHIBITORS IN HEART DISEASE
August 2018 JCI Insight
ACUTE ENHANCEMENT OF CARDIAC FUNCTION BY PHOSPHODIESTERASE TYPE 1 INHIBITION
October 2018 Circulation
TRANSIENT RECEPTOR POTENTIAL CHANNEL 6 REGULATES ABNORMAL CARDIAC S-NITROSYLATION IN DUCHENNE MUSCULAR DYSTROPHY
December 2017 PNAS
NEONATAL TRANSPLANTATION CONFERS MATURATION OF PSC-DERIVED CARDIOMYOCYTES CONDUCIVE TO MODELING CARDIOMYOPATHY
January 2017 Cell Rep
TETRAHYDROBIOPTERIN PROTECTS AGAINST HYPERTROPHIC HEART DISEASE INDEPENDENT OF MYOCARDIAL NITRIC OXIDE SYNTHASE COUPLING
March 2016 J Am Heart Assoc
PACEMAKER-INDUCED TRANSIENT ASYNCHRONY SUPPRESSES HEART FAILURE PROGRESSION.
Dec 2015 Sci Transl Med
DUAL LABELING BIOTIN SWITCH ASSAY TO REDUCE BIAS DERIVED FROM DIFFERENT CYSTEINE SUBPOPULATIONS: A METHOD TO MAXIMIZE S-NITROSYLATION DETECTION
January 25, 2025
PREVENTION OF PKG1Α OXIDATION AUGMENTS CARDIOPROTECTION IN THE STRESSED HEART
June 2015 JCI
PHOSPHODIESTERASE 9A CONTROLS NITRIC-OXIDE-INDEPENDENT CGMP AND HYPERTROPHIC HEART DISEASE
March 2015 Nature
SOLUBLE GUANYLATE CYCLASE IS REQUIRED FOR SYSTEMIC VASODILATION BUT NOT POSITIVE INOTROPY INDUCED BY NITROXYL IN THE MOUSE
February 2015 Hypertension
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